Potential molecular mechanisms for decreased synaptic glutamate release in dysbindin-1 mutant mice
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چکیده
منابع مشابه
Loss of dysbindin-1, a risk gene for schizophrenia, leads to impaired group 1 metabotropic glutamate receptor function in mice
The expression of dysbindin-1, a protein coded by the risk gene dtnbp1, is reduced in the brains of schizophrenia patients. Evidence indicates a role of dysbindin-1 in dopaminergic and glutamatergic transmission. Glutamatergic transmission and plasticity at excitatory synapses is critically regulated by G-protein coupled metabotropic glutamate receptor (mGluR) family members, that have been imp...
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ژورنال
عنوان ژورنال: Schizophrenia Research
سال: 2013
ISSN: 0920-9964
DOI: 10.1016/j.schres.2013.01.037